I was idly listening to a few podcasts on the subway and found one that caught my attention...only I can't find it again with on my iPod or using the site search.

Here's what I remember: Echo and another voice actress did the dialogue, the other actress had a gravelly type of voice (ala Marge Simpson) and Brendan went over a grammar structure that was something along the lines of "I wish I'd known..." and there was another way of saying wish/hope in addition to 希望. Seem to remember that weight loss was involved at some point too.

Sorry for the hazy description, but any help would be appreciated :)